Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.43 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3698238 | 1.00 | NTRK1 (0.61) | NTRK1JAK2AURKAAURKBABL1 | |
| SCHEMBL3781243 | 0.89 | NTRK1 (0.77) | NTRK1JAK2AURKAABL1FGR | |
| SCHEMBL3774696 | 0.88 | NTRK1 (0.72) | NTRK1JAK2ABL1FGRFGFR1 | |
| SCHEMBL3705688 | 0.86 | NTRK1 (0.59) | NTRK1JAK2AURKAAURKBABL1 | |
| SCHEMBL3702483 | 0.84 | NTRK1 (0.58) | NTRK1JAK2AURKAAURKBABL1 | |
| SCHEMBL4696821 | 0.83 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL27689887 | 0.83 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL4696858 | 0.83 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL4696616 | 0.80 | AURKA (0.47) | NTRK1JAK2AURKAAURKBABL1 | |
| SCHEMBL56315 | 0.77 | NTRK1 (0.59) | NTRK1JAK2AURKAAURKBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101119988-A | Chemical compound | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | claimed |
| CN-101119988-A | Chemical compound | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | disclosed |