Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.55 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496056 | 1.00 | ANPEP (0.55) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL4044665 | 1.00 | ANPEP (0.55) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL3347864 | 1.00 | ANPEP (0.55) | ANPEPERAP2ADRB2CSNK1EF2 | |
| Hydrochloric Acid SCHEMBL496686 | 0.98 | ANPEP (0.54) | ANPEPERAP2ADRB2CSNK1EF2 | |
| Hydrochloric Acid SCHEMBL5219517 | 0.98 | ANPEP (0.54) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL3348102 | 0.92 | ANPEP (0.48) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL3348066 | 0.92 | KDM4E (0.51) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL3357077 | 0.92 | ANPEP (0.48) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL6890169 | 0.92 | ANPEP (0.48) | ANPEPERAP2ADRB2CSNK1EF2 | |
| SCHEMBL4038793 | 0.92 | ANPEP (0.48) | ANPEPERAP2ADRB2CSNK1EF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |
| EP-1910317-A1 | 1-AMINO LINKED COMPOUNDS | Eli Lilly and Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015805-A1 | 1-AMINO LINKED COMPOUNDS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |