Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697331 | 0.87 | NTRK1 (0.67) | NTRK1JAK2KCNH2CCNT1CDK9 | |
| SCHEMBL56315 | 0.87 | NTRK1 (0.59) | NTRK1JAK2KCNH2CCNT1CDK9 | |
| SCHEMBL4697091 | 0.85 | NTRK1 (0.65) | NTRK1JAK2KCNH2 | |
| SCHEMBL4695246 | 0.84 | NTRK1 (0.51) | NTRK1JAK2KCNH2CCNT1CDK9 | |
| SCHEMBL4695227 | 0.82 | CCNT1 (0.47) | NTRK1JAK2KCNH2CCNT1CDK9 | |
| SCHEMBL3775158 | 0.78 | NTRK1 (1.00) | NTRK1JAK2ALK | |
| SCHEMBL3773405 | 0.78 | NTRK1 (1.00) | NTRK1JAK2ALK | |
| SCHEMBL3766926 | 0.76 | NTRK1 (0.75) | NTRK1JAK2KCNH2ALK | |
| SCHEMBL3778126 | 0.76 | NTRK1 (0.75) | NTRK1JAK2KCNH2ALK | |
| SCHEMBL3132402 | 0.74 | NTRK1 (0.46) | NTRK1JAK2KCNH2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |