Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705689 | 0.88 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL27709595 | 0.88 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL4750903 | 0.86 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL56800 | 0.86 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL4696829 | 0.85 | NTRK1 (0.64) | NTRK1KCNH2JAK2 | |
| SCHEMBL4697302 | 0.85 | NTRK1 (0.55) | NTRK1NUAK1 | |
| SCHEMBL57991 | 0.84 | NTRK1 (0.51) | NTRK1NUAK1 | |
| SCHEMBL4694092 | 0.83 | NTRK1 (0.48) | NTRK1NUAK1 | |
| SCHEMBL4697163 | 0.82 | NTRK1 (0.47) | NTRK1NUAK1 | |
| SCHEMBL4695287 | 0.82 | NTRK1 (0.62) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |