Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.73 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17067870 | 1.00 | RIPK1 (0.73) | RIPK1SCD5LMNATSHRJAK2 | |
| SCHEMBL17067869 | 1.00 | RIPK1 (0.73) | RIPK1SCD5LMNATSHRJAK2 | |
| SCHEMBL878861 | 0.86 | NPSR1 (0.56) | RIPK1SCD5LMNATSHRNPSR1 | |
| SCHEMBL21207072 | 0.85 | RIPK1 (0.53) | RIPK1LMNATSHRNPSR1MAPT | |
| SCHEMBL4718386 | 0.85 | RIPK1 (0.53) | RIPK1LMNATSHRNPSR1MAPT | |
| SCHEMBL31226555 | 0.85 | RIPK1 (0.53) | RIPK1LMNATSHRNPSR1MAPT | |
| SCHEMBL3663950 | 0.85 | USP30 (0.53) | RIPK1SCD5LMNATSHRNPSR1 | |
| SCHEMBL21198773 | 0.85 | RIPK1 (0.53) | RIPK1LMNATSHRNPSR1MAPT | |
| SCHEMBL22505052 | 0.85 | USP30 (0.53) | RIPK1SCD5LMNATSHRNPSR1 | |
| SCHEMBL14558793 | 0.85 | RIPK1 (0.53) | RIPK1LMNATSHRNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012116217-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |