Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700824 | 0.90 | ACE (0.42) | TRPV1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4698276 | 0.83 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4700878 | 0.83 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4755672 | 0.80 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4786303 | 0.78 | ACE (0.50) | TRPV1ACECA12CA1CA2 | |
| SCHEMBL4786307 | 0.78 | ACE (0.50) | TRPV1ACECA12CA1CA2 | |
| SCHEMBL4697067 | 0.78 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4697001 | 0.78 | MAPK8 (0.43) | KDM5BMAPK8 | |
| SCHEMBL4700050 | 0.77 | KDM5B (0.36) | KDM5BMAPK8 | |
| SCHEMBL4755310 | 0.77 | CA1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |