Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778637 | 0.82 | CCR2 (0.56) | DRD4CCR2KCNH2SMN1; SMN2 | |
| SCHEMBL1778054 | 0.80 | CHRM4 (0.49) | DRD2DRD4CCR2KCNH2CHRM4 | |
| SCHEMBL1779131 | 0.79 | CCR2 (0.53) | DRD2DRD4CCR2KCNH2 | |
| SCHEMBL1779327 | 0.77 | CCR2 (0.50) | DRD2DRD4CCR2KCNH2 | |
| SCHEMBL1778415 | 0.75 | CCR2 (0.64) | CCR2KCNH2 | |
| SCHEMBL4857247 | 0.72 | CCR2 (0.40) | CCR2KCNH2MAPTSMN1; SMN2TACR3 | |
| SCHEMBL10203195 | 0.66 | KDM2B (0.49) | DRD4MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27620712 | 0.65 | HRH3 (0.61) | MAPTSMN1; SMN2GPR119L3MBTL1 | |
| SCHEMBL24008768 | 0.65 | KMT2A (0.47) | SMN1; SMN2CHRM4 | |
| SCHEMBL30596499 | 0.65 | KDM4E (0.46) | DRD4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966187-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071952-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |