Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PTGES | O14684 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576474 | 0.84 | PTGES (0.71) | MAP4K4PTGESLDHAKCNH2ALDH1A1 | |
| SCHEMBL3578255 | 0.81 | PTGES (0.69) | PTGESPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3569096 | 0.77 | PTGES (0.43) | MAP4K4PTGESPDE4APDE4BPDE4C | |
| SCHEMBL3578441 | 0.75 | PTGES (0.47) | PTGESKCNH2EPHX2 | |
| SCHEMBL4923166 | 0.73 | EPHX2 (0.39) | PTGESALDH1A1TSHREPHX2 | |
| SCHEMBL3572573 | 0.73 | PTGES (0.56) | PTGESKCNH2ALDH1A1EPHX2 | |
| SCHEMBL3574897 | 0.73 | PTGES (0.40) | PTGESPDE4APDE4BKCNH2ALDH1A1 | |
| SCHEMBL3574806 | 0.73 | PTGES (0.85) | PTGESLDHAALDH1A1TSHR | |
| SCHEMBL3579749 | 0.73 | HRH3 (0.43) | PTGESTSHR | |
| SCHEMBL4228938 | 0.72 | PTGES (0.57) | PTGESPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778632-B1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1778632-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005123673-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2005-12-29 | — | — | WO | disclosed |