Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.61 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709798 | 1.00 | NTRK1 (0.61) | NTRK1IGF1RJAK2 | |
| SCHEMBL4696858 | 0.85 | NTRK1 (0.81) | NTRK1IGF1RJAK2 | |
| SCHEMBL4696821 | 0.85 | NTRK1 (0.81) | NTRK1IGF1RJAK2 | |
| SCHEMBL57380 | 0.85 | NTRK1 (0.62) | NTRK1IGF1RJAK2 | |
| SCHEMBL27689887 | 0.85 | NTRK1 (0.81) | NTRK1IGF1RJAK2 | |
| SCHEMBL3812515 | 0.76 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL3772425 | 0.76 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL3779322 | 0.75 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL4160397 | 0.74 | NTRK1 (0.50) | NTRK1IGF1RJAK2 | |
| SCHEMBL4144686 | 0.73 | NTRK1 (1.00) | NTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |
| CN-101119988-A | Chemical compound | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | disclosed |