Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 7/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743890 | 0.89 | CHEK1 (0.46) | PRKCZCHRNB2CHRNA4PDE7ACHEK1 | |
| SCHEMBL27981876 | 0.86 | PDE7A (0.47) | PRKCZCHRNB2CHRNA4PDE7ACHEK1 | |
| SCHEMBL27981853 | 0.85 | PRKCZ (0.41) | PRKCZCHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL8572594 | 0.82 | PRKCZ (0.43) | PRKCZCHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL27981561 | 0.82 | CHEK1 (0.44) | PRKCZPDE7ACHEK1ROCK1 | |
| SCHEMBL221461 | 0.82 | PRKCZ (0.43) | PRKCZCHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL27981878 | 0.80 | ROCK1 (0.43) | PRKCZCHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL1911989 | 0.74 | ROCK1 (0.46) | PRKCZCHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL27981849 | 0.70 | KDM4E (0.41) | CHRNB2CHRNA4 | |
| SCHEMBL27981569 | 0.70 | TP53 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316853-B | Benzothiazole and thiazolopyridine as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC | 2014-09-24 | — | — | CN | disclosed |
| EP-1910385-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019346-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |