Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.89 |
| ▸ | BTK | Q06187 | 4/20 | 0.89 |
| ▸ | ABL1 | P00519 | 3/20 | 0.89 |
| ▸ | BCR | P11274 | 3/20 | 0.89 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.89 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.89 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.89 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.89 |
| ▸ | AGPS | O00116 | 2/20 | 0.89 |
| ▸ | MYO1F | O00160 | 2/20 | 0.89 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.89 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.89 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.89 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.89 |
| ▸ | PGRMC1 | O00264 | 2/20 | 0.89 |
| ▸ | CLIC1 | O00299 | 2/20 | 0.89 |
| ▸ | CDC7 | O00311 | 2/20 | 0.89 |
| ▸ | IPO5 | O00410 | 2/20 | 0.89 |
| ▸ | PLK4 | O00444 | 2/20 | 0.89 |
| ▸ | COXFA4 | O00483 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699731 | 0.94 | ABL1 (1.00) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL29358745 | 0.94 | ABL1 (1.00) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL29380618 | 0.94 | ABL1 (1.00) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL4698636 | 0.92 | BRAF (0.76) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL24532059 | 0.91 | ABL1 (0.86) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL22024717 | 0.90 | BRAF (0.72) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL4696222 | 0.90 | BRAF (0.72) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL22119546 | 0.88 | BRAF (0.82) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL21943587 | 0.87 | BRAF (0.70) | BRAFBTKABL1BCRESYT2 | |
| SCHEMBL24532075 | 0.87 | BRAF (0.89) | BRAFBTKABL1BCRESYT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | HOLZER PHILIPP | 2008-11-06 | — | — | US | claimed |
| EP-1963327-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | Novartis AG (CH) | 2008-09-03 | — | — | EP | claimed |
| WO-2007062805-A1 | 3-(SUBSTITUTED AMINO)-PYRAZOLO[3,4-d]PYRIMIDINES AS EPHB AND VEGFR2 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-06-07 | — | — | WO | claimed |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2022-06-23 | — | — | US | disclosed |
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | HOLZER PHILIPP | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275054-A1 | 3-(Substituted Amino)-Pyrazolo[3, 4-D]Pyrimidines as Ephb and Vegfr2 Kinase Inhibitors | EPHB3, EPHB2, EPHB1 | BRAF 42/4885BTK 214/4885ABL1 30/4885 |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | EPHA1, EPHB2, EPHB1 | BRAF 52/4885BTK 140/4885ABL1 75/4885 |
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | BRAF 65/4885BTK 594/4885ABL1 1429/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | BRAF 65/4885BTK 594/4885ABL1 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.