Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2378965 | 0.99 | OPRM1 (0.41) | OPRM1OPRL1OPRK1HSD11B1OGFRL1 | |
| SCHEMBL2781209 | 0.86 | OPRM1 (0.57) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL2380060 | 0.85 | OPRL1 (0.55) | OPRM1OPRL1OPRK1 | |
| SCHEMBL2378955 | 0.83 | OPRM1 (0.52) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL2379208 | 0.79 | EGFR (0.44) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL303289 | 0.79 | EGFR (0.43) | OPRM1OPRL1OPRK1 | |
| SCHEMBL2379624 | 0.77 | OPRL1 (0.54) | OPRM1OPRL1 | |
| SCHEMBL2378267 | 0.76 | OPRM1 (0.53) | OPRM1OPRL1 | |
| SCHEMBL517788 | 0.76 | OPRM1 (0.44) | OPRM1OPRL1OPRK1HSD11B1OGFRL1 | |
| Hydrochloric Acid SCHEMBL302160 | 0.76 | OPRL1 (0.53) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |