Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693140 | 0.92 | MEN1 (0.49) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL4695165 | 0.92 | MEN1 (0.47) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL4696987 | 0.89 | MEN1 (0.46) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL2644838 | 0.86 | MEN1 (0.55) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL4697978 | 0.84 | MEN1 (0.52) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL2643572 | 0.78 | MEN1 (0.56) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL2643643 | 0.78 | MEN1 (0.54) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL2644337 | 0.77 | ALDH1A1 (0.69) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL2643615 | 0.76 | MEN1 (0.53) | MEN1KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL2643916 | 0.74 | MEN1 (0.59) | MEN1KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620425-B1 | SUBSTITUTED 3-CYANOTHIOPHENE ACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | claimed |