SCHEMBL4698048

SCHEMBL4698048

Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2(C)CCN(C(=O)OCC(C)C)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB1 P46663 20/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4172644 0.87 BDKRB1 (0.57) BDKRB1
SCHEMBL4696824 0.86 BDKRB1 (0.71) BDKRB1
SCHEMBL4699668 0.84 BDKRB1 (0.74) BDKRB1
SCHEMBL4172646 0.82 BDKRB1 (0.70) BDKRB1
SCHEMBL4698406 0.81 BDKRB1 (0.53) BDKRB1
SCHEMBL4698141 0.81 BDKRB1 (0.53) BDKRB1
SCHEMBL4789780 0.78 BDKRB1 (0.59) BDKRB1
SCHEMBL4697776 0.76 BDKRB1 (0.62) BDKRB1
SCHEMBL4161989 0.75 BDKRB1 (0.82) BDKRB1
SCHEMBL4168565 0.75 BDKRB1 (0.82) BDKRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963285-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS Amgen Inc. (US) 2008-09-03 EP claimed
WO-2007067629-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS AMGEN INC. (US) 2007-06-14 WO claimed