SCHEMBL4789780

SCHEMBL4789780

Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)NC2(C)CC[N+](C(=O)[O-])(C(C)(C)C)CC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB1 P46663 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4172646 0.85 BDKRB1 (0.70) BDKRB1
SCHEMBL4754932 0.85 BDKRB1 (0.74) BDKRB1
SCHEMBL4172644 0.82 BDKRB1 (0.57) BDKRB1
SCHEMBL3536370 0.79 BDKRB1 (0.65) BDKRB1
SCHEMBL3535119 0.78 BDKRB1 (0.68) BDKRB1
SCHEMBL4698048 0.78 BDKRB1 (0.57) BDKRB1
SCHEMBL4695986 0.76 BDKRB1 (0.64) BDKRB1
SCHEMBL4696477 0.76 BDKRB1 (0.62) BDKRB1
SCHEMBL4174736 0.75 BDKRB1 (0.76) BDKRB1
SCHEMBL4699609 0.75 BDKRB1 (0.62) BDKRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963285-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS Amgen Inc. (US) 2008-09-03 EP disclosed
WO-2007067629-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS AMGEN INC. (US) 2007-06-14 WO disclosed