Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 4/20 | 0.36 |
| ▸ | NOS3 | P29474 | 7/20 | 0.36 |
| ▸ | NOS2 | P35228 | 5/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148695 | 0.70 | KDM4E (0.49) | NOS3NOS2KDM4EALDH1A1POLB | |
| SCHEMBL8006401 | 0.70 | CYP3A4 (0.55) | KDM4EALDH1A1 | |
| SCHEMBL4748664 | 0.69 | HTR2A (0.58) | ANPEPNOS3NOS2HTR2A | |
| SCHEMBL467591 | 0.68 | DRD4 (0.45) | NOS3KDM4EALDH1A1POLB | |
| SCHEMBL31373438 | 0.64 | — | — | |
| SCHEMBL2463276 | 0.64 | — | — | |
| SCHEMBL31373436 | 0.64 | — | — | |
| SCHEMBL20863915 | 0.64 | HTR2A (0.35) | ANPEPNOS3NOS2HTR2A | |
| SCHEMBL18952772 | 0.64 | MAPT (0.40) | KDM4EALDH1A1POLB | |
| SCHEMBL11185918 | 0.64 | CDK8 (0.53) | ANPEPNOS3NOS2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960382-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |