⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961350 | 0.71 | — | — | |
| SCHEMBL423699 | 0.67 | — | — | |
| SCHEMBL8158051 | 0.67 | — | — | |
| SCHEMBL5443341 | 0.67 | — | — | |
| SCHEMBL967288 | 0.63 | — | — | |
| SCHEMBL338264 | 0.59 | KDM4E (0.34) | — | |
| SCHEMBL21611711 | 0.59 | — | — | |
| SCHEMBL785147 | 0.59 | — | — | |
| SCHEMBL43426 | 0.59 | — | — | |
| SCHEMBL1123 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273787-B2 | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions | ONCONOVA THERAPEUTICS, INC (US) | 2012-09-25 | — | — | US | claimed |
| CN-101624593-B | siRNA tumor developer and siRNA thereof | UNIV PEKING FIRST HOSPITAL | 2012-01-04 | — | — | CN | disclosed |
| CN-101624593-A | siRNA tumor developer and siRNA thereof | PEKING UNIVERSITY FIRST HOSPIT | 2010-01-13 | — | — | CN | disclosed |
| EP-1444202-B1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| US-7132434-B2 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2006-11-07 | — | — | US | disclosed |
| US-20050026990-A1 | Novel metalloproteinase ihibitors | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | disclosed |
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |