Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | UBE2N | P61088 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | TEK | Q02763 | 6/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787286 | 0.91 | KDM4E (0.58) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL1784291 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL1785934 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6748469 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4697230 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4530280 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4530804 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4750650 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4521405 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4697914 | 0.77 | KDM4E (0.63) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131859-A2 | USE OF CYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |
| EP-1966218-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079861-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |