Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698709 | 0.89 | — | — | |
| SCHEMBL4698193 | 0.88 | BACE1 (0.40) | BACE1CTSDCYP3A4KDM1AKCNN4 | |
| SCHEMBL2351125 | 0.71 | BACE1 (0.40) | BACE1 | |
| SCHEMBL1420518 | 0.71 | KDM1A (0.59) | KDM1AKCNN4SLC6A4OPRL1SLC6A3 | |
| SCHEMBL4700710 | 0.70 | KIF11 (0.36) | CYP3A4 | |
| Hydrochloric Acid SCHEMBL3001569 | 0.70 | KDM1A (0.57) | KDM1AKCNN4SLC6A4OPRL1SLC6A3 | |
| SCHEMBL27426482 | 0.69 | KDM1A (0.37) | KDM1ASLC6A4 | |
| SCHEMBL2525890 | 0.68 | KDM4E (0.39) | CYP3A4 | |
| SCHEMBL2871341 | 0.68 | KDM1A (0.41) | BACE1KDM1AKCNN4SLC6A4 | |
| Hydrochloric Acid SCHEMBL3581155 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937638-A1 | METHODS OF TREATING AMYLOIDOSIS USING ARYL-CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | Elan Pharmaceuticals Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007047306-A1 | METHODS OF TREATING AMYLOIDOSIS USING ARYL-CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |