Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 10/20 | 0.40 |
| ▸ | MC5R | P33032 | 6/20 | 0.40 |
| ▸ | MC3R | P41968 | 5/20 | 0.40 |
| ▸ | MC1R | Q01726 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700944 | 0.92 | MC4R (0.39) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4699883 | 0.88 | MCL1 (0.41) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4699880 | 0.86 | MAPK1 (0.44) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4701772 | 0.85 | MC4R (0.45) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4701927 | 0.85 | MC4R (0.43) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4701498 | 0.84 | MC4R (0.46) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4697980 | 0.84 | MC4R (0.51) | MC4RMC5RMC3RMC1R | |
| SCHEMBL4699046 | 0.84 | MAPK1 (0.43) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4704216 | 0.83 | MAPK1 (0.45) | MCL1MC4RMC5RMC3RMC1R | |
| SCHEMBL4698437 | 0.83 | MC4R (0.44) | MCL1MC4RMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | disclosed |
| US-6977264-B2 | Substituted piperidines and methods of use | AMGEN INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-20040006067-A1 | Substituted piperidines and methods of use | AMGEN INC. | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006067-A1 | Substituted piperidines and methods of use | MC4R, MC5R, MC1R | MCL1 3342/4885MC4R 1/4885MC5R 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.