Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 11/20 | 0.39 |
| ▸ | MC5R | P33032 | 5/20 | 0.39 |
| ▸ | MC3R | P41968 | 5/20 | 0.39 |
| ▸ | MC1R | Q01726 | 5/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698359 | 0.92 | MCL1 (0.41) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4697980 | 0.87 | MC4R (0.51) | MC4RMC5RMC3RMC1R | |
| SCHEMBL4699796 | 0.85 | TACR1 (0.40) | MC4RMC5RMC3RMC1RCYP51A1 | |
| SCHEMBL4701820 | 0.83 | MC4R (0.41) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4697983 | 0.83 | MC4R (0.40) | MC4RMC5RMC3RMC1RCYP51A1 | |
| SCHEMBL4754436 | 0.83 | MC4R (0.43) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4700243 | 0.83 | MC4R (0.44) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4698168 | 0.82 | MC4R (0.45) | MC4RMC5RMC3RMC1RCYP51A1 | |
| SCHEMBL4699523 | 0.81 | RBP4 (0.45) | MC4RMC5RMC3RMC1RCYP3A4 | |
| SCHEMBL4700875 | 0.81 | MC4R (0.46) | MC4RMC5RMC3RMC1RCYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | disclosed |