Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ACR | P10323 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697781 | 0.90 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4698884 | 0.80 | ACR (0.47) | ADORA3ADORA2AADORA2BADORA1ACR | |
| SCHEMBL4696716 | 0.80 | ACR (0.44) | ADORA3ADORA2AADORA2BADORA1ACR | |
| SCHEMBL4699027 | 0.79 | NPC1 (0.38) | ADORA3ADORA2AADORA2BADORA1ACR | |
| SCHEMBL4677541 | 0.79 | MAPT (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4677543 | 0.79 | MAPT (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4703241 | 0.78 | GAA (0.37) | ADORA3ADORA2AADORA2BADORA1ACR | |
| SCHEMBL4698276 | 0.78 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4058001 | 0.77 | ADORA1 (0.45) | ADORA3ADORA2AADORA2BADORA1ACR | |
| SCHEMBL4697523 | 0.77 | MAPK14 (0.46) | ADORA3ADORA2AADORA2BADORA1ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |