ACR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Camostat (SCHEMBL125270)	0.61	10/20
Nafamostat (SCHEMBL135504)	0.60	9/20
SCHEMBL1404357	0.51	9/20
Nafamostat (SCHEMBL1650158)	0.68	8/20
SCHEMBL1649708	0.73	7/20
SCHEMBL107649	0.50	6/20
SCHEMBL346698	0.50	6/20
SCHEMBL347429	0.50	6/20
SCHEMBL548392	0.56	5/20
SCHEMBL107413	0.55	5/20
SCHEMBL1683932	0.55	5/20
SCHEMBL141627	0.52	4/20
SCHEMBL547590	0.51	4/20
SCHEMBL141556	0.48	4/20
SCHEMBL269548	0.43	4/20
SCHEMBL532763	0.62	3/20
SCHEMBL702242	0.61	3/20
SCHEMBL1686535	0.56	3/20
SCHEMBL678424	0.53	3/20
SCHEMBL1421354	0.51	3/20

Clinical trials — most relevant to ACR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors	PHASE1	RECRUITING
Home Semen Analysis Tests As a Screening Tool for Fertility Patients	EARLY_PHASE1	COMPLETED
The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc in Men With Idiopathic Asthenozoospermia	EARLY_PHASE1	UNKNOWN
Probiotics on Sperm Quality in Male Infertility Patients	nan	RECRUITING
Acrosome Reaction Induction Prior to ICSI	nan	COMPLETED
The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients：A Prospective Cohort Study	nan	UNKNOWN
Vitamin D Level vs Semen Parameters	nan	UNKNOWN
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection	nan	COMPLETED
Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (ICSI)	nan	COMPLETED
Cryogenic Preservation of Spermatozoa	nan	COMPLETED
Hypotaurine Supplementation Benefits in Cryopreservation	nan	COMPLETED
The Role of HE4 in the Follow-up of Advanced Ovarian, Fallopian Tube and Primary Peritoneal Cancer	nan	UNKNOWN
Evaluation of Fertitonex Effects on Semen Parameters in Clinical Varicocele Patient.	nan	RECRUITING
Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male Infertility	nan	RECRUITING
DNA Fragmentation - Effect on Pregnancy Rate	nan	COMPLETED
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility	nan	COMPLETED
Human Sperm Epigenetics in Embryonic Development.	nan	COMPLETED
Male Infertility Related With Post Infection Inflammatory Syndrome	nan	COMPLETED
Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors	nan	RECRUITING
The Effects of Autologous Platelet-rich Plasma Supplement During Sperm Cryopreservation on Post-cryopreserved Sperm Quality	nan	UNKNOWN
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.	nan	UNKNOWN
Use of the SiDTM v2.0 Algorithm to Assist Embiyologists in Sperm Selection During ICSI Procedures	nan	NOT_YET_RECRUITING
Characterization of Sperm Population Following Different Selection Procedures	nan	UNKNOWN
Testicular Function After Testicular Torsion	nan	UNKNOWN
A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom	nan	COMPLETED
Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation	nan	RECRUITING
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)	nan	UNKNOWN
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications	nan	UNKNOWN
Impact of Nuclear Human Sperm Quality on Embryo Development	nan	UNKNOWN
A First in Human Study, Evaluating the Safety and Efficacy of ADAM™ 1.0	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACR binder may also engage these)

Protein	Name	Similarity
P08001	—	1.000	P08001 →
P29293	—	1.000	P29293 →
P23578	—	0.998	P23578 →
P48038	—	0.997	P48038 →
Q3UQ41	—	0.992	Q3UQ41 →
P29598	—	0.989	P29598 →
P18292	—	0.988	P18292 →
P49150	—	0.988	P49150 →
Q5U405	—	0.987	Q5U405 →
Q1L659	—	0.986	Q1L659 →
Q6ZWK6	—	0.986	Q6ZWK6 →
P04185	—	0.986	P04185 →
Q8BHM9	—	0.986	Q8BHM9 →
Q804X6	—	0.985	Q804X6 →
Q9GL10	—	0.985	Q9GL10 →
Q9WUW3	—	0.985	Q9WUW3 →
P19221	—	0.985	P19221 →
P19637	—	0.985	P19637 →
Q8MHY7	—	0.985	Q8MHY7 →
P28175	—	0.985	P28175 →
P33587	—	0.984	P33587 →
Q5R537	—	0.984	Q5R537 →
Q5E9Z2	—	0.984	Q5E9Z2 →
Q5R8J0	—	0.984	Q5R8J0 →
Q9JIQ8	—	0.984	Q9JIQ8 →
Q5E9P5	—	0.984	Q5E9P5 →
P11214	—	0.984	P11214 →
O88947	—	0.984	O88947 →
Q58L93	—	0.984	Q58L93 →
Q28801	—	0.984	Q28801 →