Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16884088 | 0.83 | HTT (0.76) | HTTSMN1; SMN2PDE4BKMT2AMEN1 | |
| SCHEMBL20468154 | 0.82 | HRH3 (0.50) | HTTSMN1; SMN2NPC1TP53TSHR | |
| SCHEMBL2927968 | 0.80 | KDM4E (0.53) | SMN1; SMN2KMT2AMEN1TP53TSHR | |
| SCHEMBL28290185 | 0.79 | HTT (0.70) | HTTSMN1; SMN2PDE4BKMT2AMEN1 | |
| SCHEMBL18648216 | 0.79 | HRH3 (0.50) | HTTSMN1; SMN2CHEK1NPC1TP53 | |
| SCHEMBL496015 | 0.79 | HRH3 (0.50) | HTTSMN1; SMN2PDE4BCHEK1NPC1 | |
| SCHEMBL20247420 | 0.79 | HTT (0.55) | HTTSMN1; SMN2CHEK1KMT2AMEN1 | |
| SCHEMBL519845 | 0.79 | HTT (0.70) | HTTSMN1; SMN2PDE4BKMT2AMEN1 | |
| SCHEMBL18648036 | 0.77 | HTT (0.42) | HTTSMN1; SMN2PDE4BKMT2AMEN1 | |
| SCHEMBL5755240 | 0.77 | HTT (0.67) | HTTSMN1; SMN2PDE4BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |