Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698450 | 0.80 | MAPT (0.55) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL28884203 | 0.78 | GAA (0.68) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL21538104 | 0.78 | KMT2A (0.64) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL31105723 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL7748696 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL7748700 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7747576 | 0.76 | MAPT (0.54) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL21519408 | 0.76 | KMT2A (0.63) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7747578 | 0.76 | MAPT (0.54) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL4697181 | 0.76 | RXFP3 (0.52) | MAPTALDH1A1CYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309544-B1 | COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS | ACURE PHARMA AB (SE) | 2008-11-05 | — | — | EP | claimed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | claimed |
| EP-1309544-B1 | COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS | ACURE PHARMA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | disclosed |