Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.43 |
| ▸ | HTR2C | P28335 | 9/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 9/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244165 | 0.99 | HTR2A (0.44) | HTR2AHTR2CSSTR2PRKCZ | |
| SCHEMBL5243079 | 0.97 | HTR2A (0.44) | HTR2AHTR2CSSTR2PRKCZ | |
| SCHEMBL5243165 | 0.84 | HTR2A (0.47) | HTR2AHTR2CSSTR2 | |
| SCHEMBL3952777 | 0.82 | HTR2A (0.41) | HTR2AHTR2CSSTR2 | |
| SCHEMBL5246780 | 0.81 | HTR2A (0.57) | HTR2AHTR2C | |
| SCHEMBL5242075 | 0.80 | HTR2A (0.53) | HTR2AHTR2C | |
| SCHEMBL5242697 | 0.80 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL5327071 | 0.80 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL1165844 | 0.80 | HTR2A (0.63) | HTR2AHTR2C | |
| SCHEMBL5245092 | 0.80 | HTR2A (0.61) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978019-A1 | 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | Arena Pharmaceuticals, Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| EP-1833799-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT-2a SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006055734-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |