Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.44 |
| ▸ | HTR2C | P28335 | 11/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | SSTR2 | P30874 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698783 | 0.97 | HTR2A (0.43) | HTR2AHTR2CPRKCZSSTR2 | |
| SCHEMBL5244165 | 0.96 | HTR2A (0.44) | HTR2AHTR2CPRKCZSSTR2 | |
| SCHEMBL5243165 | 0.86 | HTR2A (0.47) | HTR2AHTR2CSSTR2 | |
| SCHEMBL5246780 | 0.83 | HTR2A (0.57) | HTR2AHTR2C | |
| SCHEMBL4126600 | 0.81 | HTR2A (0.41) | HTR2AHTR2CMKNK1 | |
| SCHEMBL5244726 | 0.81 | HTR2A (0.51) | HTR2AHTR2C | |
| SCHEMBL1165844 | 0.81 | HTR2A (0.63) | HTR2AHTR2C | |
| SCHEMBL1166100 | 0.80 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL1165825 | 0.80 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL1166558 | 0.80 | HTR2A (0.46) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833799-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT-2a SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006055734-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |