Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025644 | 0.83 | ALDH1A1 (0.51) | KDM4ECHRM2CHRM5CHRM3DRD4 | |
| SCHEMBL4702906 | 0.81 | SMN1; SMN2 (0.49) | MMP2MMP3MMP9MMP8MMP13 | |
| SCHEMBL5368555 | 0.80 | KDM4E (0.70) | KDM4ECHRM2CHRM5CHRM3DRD4 | |
| SCHEMBL3805407 | 0.76 | KDM4E (0.55) | KDM4ECHRM2CHRM5CHRM3MEN1 | |
| SCHEMBL5993383 | 0.75 | MAPT (0.51) | KDM4ECHRM2CHRM1ALDH1A1NPC1 | |
| SCHEMBL5968252 | 0.75 | KDM4E (0.46) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL4704643 | 0.74 | KIT (0.57) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL2106890 | 0.74 | STS (0.57) | KDM4ECHRM2CHRM5CHRM3DRD4 | |
| SCHEMBL3645098 | 0.74 | MEN1 (0.56) | KDM4ECHRM2CHRM5CHRM3MEN1 | |
| SCHEMBL3985529 | 0.73 | KDM4E (0.47) | KDM4ECHRM2CHRM5CHRM3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |