Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457647 | 1.00 | ERN1 (0.43) | ERN1IRAK4KDREPHA2EPHB4 | |
| SCHEMBL456990 | 0.83 | TNF (0.46) | ERN1 | |
| SCHEMBL470155 | 0.83 | TNF (0.46) | ERN1 | |
| SCHEMBL457022 | 0.83 | TNF (0.46) | ERN1 | |
| SCHEMBL10279248 | 0.82 | SCN5A (0.42) | ERN1 | |
| SCHEMBL456397 | 0.82 | TNF (0.43) | ERN1 | |
| SCHEMBL455915 | 0.82 | SCN5A (0.42) | ERN1 | |
| SCHEMBL10279502 | 0.77 | ERN1 (0.51) | ERN1 | |
| SCHEMBL17416379 | 0.74 | TTK (0.61) | ERN1 | |
| SCHEMBL457790 | 0.74 | TTK (0.61) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |