Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27934559 | 0.85 | GAA (0.42) | MAP4K4CA1CA2KDM4ELMNA | |
| SCHEMBL20672997 | 0.83 | ATR (0.39) | ATRCA1CA2KDM4ELMNA | |
| SCHEMBL24035215 | 0.81 | LCK (0.38) | ATRCA1CA2KDM4ELMNA | |
| SCHEMBL4697772 | 0.79 | ALDH1A1 (0.36) | MAP4K4ATRCA1CA2MAPKAPK2 | |
| SCHEMBL4697055 | 0.77 | MAPT (0.38) | MAP4K4ATRKDM4ELMNACDK1 | |
| SCHEMBL20064692 | 0.76 | KDR (0.57) | MAP4K4CDK1CYP17A1EGFRSRC | |
| SCHEMBL4697777 | 0.76 | ATR (0.33) | MAP4K4ATRCA1CA2MAPKAPK2 | |
| SCHEMBL21641259 | 0.76 | PTPN2 (0.43) | — | |
| SCHEMBL1554963 | 0.75 | AURKA (0.39) | MAP4K4ATRCA1CA2MAPKAPK2 | |
| SCHEMBL20064687 | 0.73 | CA12 (0.44) | MAP4K4CA1MAPKAPK2KDM4ECDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085575-B2 | Tri- and tetracyclic pyrazolo[3,4-B]pyridine compounds as antineoplastic agent | PIERRE FABRE MEDICAMENT (FR) | 2015-07-21 | — | — | US | disclosed |
| EP-2697222-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | Pierre Fabre Medicament (FR) | 2014-02-19 | — | — | EP | disclosed |
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2014-01-30 | — | — | US | disclosed |
| WO-2012140114-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2012-10-18 | — | — | WO | disclosed |
| EP-1966222-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| WO-2007059341-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | TPMT, TYMP, PAICS | MAP4K4 1910/4885ATR 788/4885CA1 1175/4885 |
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | MAP4K2, MAP4K5, MAP4K3 | MAP4K4 11/4885ATR 737/4885CA1 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.