Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | F13A1 | P00488 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527725 | 0.84 | MAPT (0.40) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2526014 | 0.82 | ALDH1A1 (0.36) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2526066 | 0.78 | ALDH1A1 (0.41) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2528439 | 0.75 | ALDH1A1 (0.40) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2529528 | 0.74 | ALDH1A1 (0.38) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL4878311 | 0.74 | HPGD (0.47) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2532552 | 0.73 | HPGD (0.44) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2533468 | 0.73 | ALDH1A1 (0.43) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2530507 | 0.73 | ALDH1A1 (0.43) | MAPTALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL2526880 | 0.73 | TSHR (0.47) | MAPTALDH1A1HPGDRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968954-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007077004-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |