Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11510145 | 0.90 | HIF1A (0.64) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| SCHEMBL11511077 | 0.89 | HIF1A (0.67) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| SCHEMBL4170185 | 0.89 | HIF1A (0.62) | HIF1APKMCYP3A4KDM4EMAPT | |
| SCHEMBL10054970 | 0.86 | HDAC8 (0.61) | HIF1APKMCYP3A4CYP1A2KDM4E | |
| SCHEMBL5181587 | 0.84 | FFAR1 (0.62) | HIF1APKMKDM4EMAPTBLM | |
| SCHEMBL2940046 | 0.84 | HIF1A (0.61) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| SCHEMBL27487037 | 0.83 | HIF1A (0.69) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| Hydrochloric Acid SCHEMBL2987245 | 0.82 | HIF1A (0.60) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| SCHEMBL4420508 | 0.82 | HIF1A (0.56) | HIF1APKMCYP3A4CYP1A2ALOX15 | |
| SCHEMBL27488835 | 0.82 | FFAR1 (0.67) | HIF1AKDM4ERAB9AHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928880-B1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | CHIESI FARM SPA (IT) | 2018-02-14 | — | — | EP | disclosed |
| EP-2928880-B1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | CHIESI FARM SPA (IT) | 2018-02-14 | — | — | EP | disclosed |
| CN-104837828-B | It is used as the phenylethyl pyridine derivate of PDE4 inhibitor | 奇斯药制品公司 | 2017-07-18 | — | — | CN | disclosed |
| CN-104277051-B | 4 aminothiophenes simultaneously [3,2 C] carboxylic acid derivates of pyridine 7 | 霍夫曼-拉罗奇有限公司 | 2017-06-09 | — | — | CN | disclosed |
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | disclosed |
| US-9199980-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-01 | — | — | US | disclosed |
| US-9199980-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-01 | — | — | US | disclosed |
| EP-2928880-A1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2015-10-14 | — | — | EP | disclosed |
| CN-104837828-A | Phenylethylpyridine derivatives as PDE4-inhibitors | CHIESI FARMA SPA | 2015-08-12 | — | — | CN | disclosed |
| CN-101263145-B | 4-amino-thieno [3,2-C ] pyridine-7-carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-02-25 | — | — | CN | disclosed |
| WO-2014086852-A1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014086852-A1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-12 | — | — | WO | disclosed |
| US-20140155427-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| US-20140155427-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| US-20140155427-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-05 | — | — | US | disclosed |
| EP-1926737-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031428-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | WO | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
| US-4152452-A | N-BENZYLANILINE AND DERIVATIVES | WILLIAM H. RORER, INC. (US) | 1979-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155427-A1 | NOVEL COMPOUNDS | CHRM3, PDE4A, PDE3A | HIF1A 2517/4885PKM 1140/4885CYP3A4 229/4885 |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BRAF, RAF1, MAP3K7 | HIF1A 1274/4885PKM 513/4885CYP3A4 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.