Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080241 | 0.79 | EGFR (0.74) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL4700054 | 0.79 | NAMPT (0.42) | EGFRERBB2NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4090572 | 0.79 | EGFR (0.74) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL1386571 | 0.79 | EGFR (0.74) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL4156430 | 0.68 | EGFR (0.61) | EGFR | |
| SCHEMBL14353338 | 0.68 | EGFR (0.53) | EGFRERBB2EPHA2EPHB4 | |
| SCHEMBL18318200 | 0.67 | PIK3CD (0.46) | NAMPTPIK3CDPIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL18318202 | 0.67 | PIK3CD (0.46) | NAMPTPIK3CDPIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL29781310 | 0.67 | EGFR (0.59) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL12838832 | 0.67 | EGFR (0.70) | EGFRERBB2EPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667991-B1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-14 | — | — | EP | claimed |