Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | KDM4A | O75164 | 2/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
| ▸ | KDM6A | O15550 | 1/20 | 0.57 |
| ▸ | TET3 | O43151 | 1/20 | 0.57 |
| ▸ | KDM4B | O94953 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.57 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.57 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700662 | 0.87 | KDM4E (0.47) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL30744931 | 0.86 | KDM4E (0.57) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL6068261 | 0.85 | KDM4E (0.68) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL6956143 | 0.83 | KDM4E (0.45) | KDM4EL3MBTL1RAB9APDE4APDE4B | |
| SCHEMBL4022814 | 0.81 | PDE4A (0.64) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| Hydrochloric Acid SCHEMBL6984422 | 0.79 | PDE4A (0.62) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| Ethane SCHEMBL27474713 | 0.79 | PDE4A (0.62) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL23489313 | 0.78 | KDM4E (0.75) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL69673 | 0.78 | KDM4E (0.77) | KDM4EL3MBTL1KDM4AEGLN1KDM6B | |
| SCHEMBL6068174 | 0.78 | KDM4E (0.62) | KDM4EL3MBTL1KDM4AEGLN1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| US-7030063-B1 | Cyclohexenonquinolinoyl-derivatives as herbicidal agents | BASF AKTIENGESELLSCHAFT (DE) | 2006-04-18 | — | — | US | disclosed |
| CN-1148189-C | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | ��������ķ������ | 2004-05-05 | — | — | CN | disclosed |
| EP-1112256-B1 | CYCLOHEXENONQUINOLINOYL-DERIVATIVES AS HERBICIDAL AGENTS | BASF AG (DE) | 2003-10-29 | — | — | EP | disclosed |
| EP-1112256-A1 | CYCLOHEXENONQUINOLINOYL-DERIVATIVES AS HERBICIDAL AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000014069-A1 | CYCLOHEXENONQUINOLINOYL-DERIVATIVES AS HERBICIDAL AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-16 | — | — | WO | disclosed |
| CN-1219131-A | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | DARWIN DISCOVERY CO LTD (GB) | 1999-06-09 | — | — | CN | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |