Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 15/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046046 | 0.86 | BDKRB1 (1.00) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL4705006 | 0.84 | BDKRB1 (0.65) | BDKRB1ALDH1A1KDM4ECCNA2CDK2 | |
| SCHEMBL4705242 | 0.84 | BDKRB1 (0.65) | BDKRB1ALDH1A1KDM4ECCNA2CDK2 | |
| SCHEMBL4701967 | 0.79 | BDKRB1 (0.57) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL6045899 | 0.79 | BDKRB1 (0.71) | BDKRB1ALDH1A1KDM4ECCNA2CDK2 | |
| SCHEMBL6045827 | 0.79 | BDKRB1 (0.71) | BDKRB1ALDH1A1KDM4ECCNA2CDK2 | |
| SCHEMBL4705179 | 0.78 | BDKRB1 (0.56) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL4705164 | 0.74 | BDKRB1 (0.51) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL14084995 | 0.73 | BDKRB1 (0.63) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL14084773 | 0.72 | BDKRB1 (0.61) | BDKRB1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |