Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705179 | 0.89 | BDKRB1 (0.56) | BDKRB1ALDH1A1KDM4ERAB9AFPR2 | |
| SCHEMBL14084995 | 0.86 | BDKRB1 (0.63) | BDKRB1ALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL4701844 | 0.84 | BDKRB1 (0.42) | BDKRB1RAB9AMEN1KMT2ACHEK1 | |
| SCHEMBL4705242 | 0.82 | BDKRB1 (0.65) | BDKRB1ALDH1A1KDM4ERAB9AFPR2 | |
| SCHEMBL4705006 | 0.82 | BDKRB1 (0.65) | BDKRB1ALDH1A1KDM4ERAB9AFPR2 | |
| SCHEMBL4700940 | 0.79 | BDKRB1 (0.75) | BDKRB1ALDH1A1KDM4E | |
| SCHEMBL4705645 | 0.79 | BDKRB1 (0.41) | BDKRB1ALDH1A1MEN1KMT2A | |
| SCHEMBL14084773 | 0.77 | BDKRB1 (0.61) | BDKRB1ALDH1A1KDM4ERAB9ACHEK1 | |
| SCHEMBL6047124 | 0.77 | BDKRB1 (0.61) | BDKRB1ALDH1A1KDM4ERAB9ACHEK1 | |
| SCHEMBL4705164 | 0.75 | BDKRB1 (0.51) | BDKRB1ALDH1A1KDM4ECHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |