Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.73 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699354 | 0.92 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL155477 | 0.84 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL4699020 | 0.84 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL4701218 | 0.83 | PDE4D (0.78) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4702946 | 0.82 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4701160 | 0.80 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4698806 | 0.80 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL92611 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL450642 | 0.77 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL30074719 | 0.77 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |