Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450642 | 0.85 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL30074719 | 0.85 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL155477 | 0.81 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4701218 | 0.80 | PDE4D (0.78) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4756526 | 0.80 | PDE4D (0.60) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4701016 | 0.80 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL92611 | 0.79 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4701160 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4699020 | 0.79 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL5022909 | 0.77 | KMT2A (0.55) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |