Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 7/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705484 | 0.91 | BDKRB1 (0.41) | BDKRB1ITGB1ITGA4ITGB7ACKR3 | |
| SCHEMBL14084923 | 0.89 | KDM2B (0.48) | KDM2BBDKRB1ACKR3DRD4CCNA2 | |
| SCHEMBL4704306 | 0.89 | BDKRB1 (0.45) | BDKRB1ITGB1ITGA4ITGB7ACKR3 | |
| SCHEMBL4700867 | 0.86 | BDKRB1 (0.46) | BDKRB1ITGB1ITGA4ITGB7DRD4 | |
| SCHEMBL4790284 | 0.86 | ITGB1 (0.49) | BDKRB1ITGB1ITGA4ITGB7ACKR3 | |
| SCHEMBL4703830 | 0.86 | BDKRB1 (0.44) | BDKRB1ITGB1ITGA4ITGB7ACKR3 | |
| SCHEMBL4705037 | 0.85 | DRD4 (0.46) | DRD4 | |
| SCHEMBL4704842 | 0.85 | DRD4 (0.46) | DRD4 | |
| SCHEMBL4700943 | 0.84 | KDM5A (0.43) | BDKRB1ITGB1ITGA4ITGB7CCNA2 | |
| SCHEMBL4705126 | 0.84 | ALDH1A1 (0.42) | BDKRB1ITGB1ITGA4ITGB7ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |