Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.46 |
| ▸ | ERN1 | O75460 | 6/20 | 0.42 |
| ▸ | FYN | P06241 | 4/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10279183 | 0.86 | TTK (0.58) | TTKFYN | |
| SCHEMBL10279096 | 0.86 | FYN (0.41) | TTKERN1FYN | |
| SCHEMBL463339 | 0.83 | TTK (0.48) | TTKERN1FYN | |
| SCHEMBL458691 | 0.80 | ERN1 (0.44) | TTKERN1FYN | |
| SCHEMBL10279181 | 0.79 | TTK (0.59) | TTKERN1FYN | |
| SCHEMBL470128 | 0.79 | TTK (0.61) | TTKERN1 | |
| SCHEMBL462985 | 0.78 | TTK (0.64) | TTK | |
| SCHEMBL10279180 | 0.78 | TTK (0.56) | TTKERN1FYN | |
| SCHEMBL470209 | 0.76 | TTK (0.56) | TTKERN1FYN | |
| SCHEMBL463338 | 0.76 | TTK (0.53) | TTKERN1FYNIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014020041-A1 | COMBINATIONS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-02-06 | — | — | WO | claimed |
| US-9255100-B2 | Substituted imidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-09 | — | — | US | disclosed |
| EP-2614063-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER IP GMBH (DE) | 2016-01-13 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |