Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481975 | 0.96 | AR (0.49) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL4704066 | 0.96 | AR (0.49) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL4484222 | 0.88 | KMT2A (0.46) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL4472275 | 0.83 | AR (0.45) | ARKMT2AMEN1MAPTKDM4E | |
| SCHEMBL14480619 | 0.81 | AR (0.43) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL14481095 | 0.81 | AR (0.43) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL21780397 | 0.81 | AR (0.43) | ARHTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL4477728 | 0.79 | AR (0.44) | ARPRMT5WDR77GRIA1ALPL | |
| SCHEMBL4489426 | 0.76 | ALPL (0.47) | ARHTR2AHTR2CHTR2BGRIA1 | |
| SCHEMBL4483125 | 0.76 | ALPL (0.47) | ARHTR2AHTR2CHTR2BGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399450-B1 | BENZOXAZEPINE DERIVATIVES AND THEIR USE AS AMPA RECEPTOR STIMULATORS | ORGANON NV (NL) | 2008-03-19 | — | — | EP | disclosed |