Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.49 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225536 | 0.82 | SSTR5 (0.49) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL3776444 | 0.82 | SSTR5 (0.68) | SSTR5SSTR1HRH1KCNH2HTR2B | |
| SCHEMBL4701211 | 0.81 | SLC6A4 (0.44) | SSTR5SSTR1HRH1KCNH2UTS2R | |
| SCHEMBL3782537 | 0.81 | SSTR5 (0.63) | SSTR5SSTR1HRH1KCNH2HTR2B | |
| SCHEMBL4703414 | 0.80 | SLC6A2 (0.40) | SSTR5SSTR1KCNH2 | |
| SCHEMBL3782200 | 0.79 | SSTR5 (0.64) | SSTR5SSTR1HRH1 | |
| SCHEMBL3782798 | 0.79 | SSTR5 (0.53) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL4231286 | 0.77 | SSTR5 (0.56) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL4230567 | 0.76 | SSTR5 (0.57) | SSTR5HRH1HTR2B | |
| SCHEMBL3774424 | 0.76 | SSTR5 (0.58) | SSTR5SSTR1HRH1KCNH2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | claimed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | claimed |