Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.42 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705064 | 0.90 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3SSTR5TACR1 | |
| SCHEMBL4703414 | 0.89 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL3977983 | 0.89 | SSTR5 (0.41) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL5558707 | 0.87 | SLC6A2 (0.48) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL4704666 | 0.86 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL4706291 | 0.84 | SLC6A2 (0.39) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL3973812 | 0.83 | SSTR5 (0.38) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL3968604 | 0.82 | SSTR5 (0.40) | SLC6A4SLC6A2SLC6A3SSTR5SSTR1 | |
| SCHEMBL4701415 | 0.81 | SSTR5 (0.49) | SSTR5SSTR1HRH1KCNH2UTS2R | |
| SCHEMBL4702470 | 0.81 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3SSTR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | claimed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | claimed |
| EP-2001867-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |