Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.67 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.62 |
| ▸ | CCKBR | P32239 | 9/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 3/20 | 0.57 |
| ▸ | BRD2 | P25440 | 3/20 | 0.57 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.57 |
| ▸ | CCKAR | P32238 | 4/20 | 0.57 |
| ▸ | GABRP | O00591 | 1/20 | 0.57 |
| ▸ | GABRD | O14764 | 1/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788080 | 0.92 | SCN9A (0.78) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL6993452 | 0.92 | SCN9A (0.78) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL4697564 | 0.89 | SCN9A (0.69) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL4420621 | 0.89 | SCN9A (0.69) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL8241722 | 0.88 | SCN9A (0.70) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL6096123 | 0.86 | CCKBR (0.69) | SCN9ASENP1CCKBRKCNH2PSEN1 | |
| SCHEMBL6098837 | 0.86 | CCKBR (0.69) | SCN9ASENP1CCKBRKCNH2PSEN1 | |
| SCHEMBL4699390 | 0.84 | HDAC3 (0.65) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL8241250 | 0.84 | SCN9A (0.67) | SCN9ASENP1CCKBRKCNH2BRD4 | |
| SCHEMBL10828856 | 0.83 | CCKBR (0.67) | SCN9ACCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326849-B1 | BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2008-07-16 | — | — | EP | disclosed |
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-6995155-B2 | Benzodiazepine derivatives as inhibitors of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2006-02-07 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
| US-20040024203-A1 | Benzodiazepine derivatives as inhibitors of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2004-02-05 | — | — | US | disclosed |
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | SCN9A 305/4885SENP1 528/4885CCKBR 642/4885 |
| US-20040024203-A1 | Benzodiazepine derivatives as inhibitors of gamma secretase | BACE1, BACE2, PSEN1 | SCN9A 337/4885SENP1 497/4885CCKBR 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.