Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699907 | 0.92 | CRBN (0.44) | CRBNTHRBBRD4CREBBPHSD17B10 | |
| SCHEMBL4702086 | 0.90 | THRB (0.47) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4703393 | 0.89 | THRB (0.46) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4703176 | 0.88 | THRB (0.44) | CRBNTHRBHSD17B10HPGDALDH1A1 | |
| SCHEMBL4703169 | 0.88 | THRB (0.46) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4700682 | 0.87 | THRB (0.45) | THRBHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL4703871 | 0.86 | THRB (0.44) | THRBHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL4700632 | 0.85 | THRB (0.43) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4703388 | 0.84 | THRB (0.48) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4703167 | 0.84 | THRB (0.48) | THRBHSD17B10HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615896-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2008-04-23 | — | — | EP | claimed |