Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699767 | 0.91 | GRM1 (0.41) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4701116 | 0.88 | GRM1 (0.40) | GRM1PTGS2MAPTPTGS1TP53 | |
| SCHEMBL4704598 | 0.88 | GRM1 (0.42) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4703457 | 0.87 | GRM1 (0.40) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4700332 | 0.87 | GRM1 (0.42) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4704989 | 0.85 | GRM1 (0.40) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4701861 | 0.85 | GRM1 (0.42) | GRM1PTGS2MAPTPTGS1RIPK2 | |
| SCHEMBL4164801 | 0.83 | GRM1 (0.59) | GRM1MAPTTP53 | |
| SCHEMBL4168810 | 0.80 | GRM1 (0.41) | GRM1PTGS2MAPTRIPK2TP53 | |
| SCHEMBL4702957 | 0.77 | PTGS2 (0.39) | GRM1PTGS2PTGS1RIPK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999132-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM, LLC (BM) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007120454-A1 | AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY | IRM LLC (BM) | 2007-10-25 | — | — | WO | disclosed |