Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL716886 | 0.83 | PIK3CG (0.45) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL470238 | 0.80 | PIK3CG (0.67) | PIK3CGPIK3CAPIK3CDPIK3CBTLR8 | |
| SCHEMBL714369 | 0.77 | PIK3CG (0.46) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL715105 | 0.77 | PIK3CG (0.71) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL13190540 | 0.76 | PIK3CA (0.42) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL715410 | 0.75 | PIK3CG (0.69) | PIK3CGPIK3CAPIK3CDPIK3CBTDO2 | |
| SCHEMBL714352 | 0.73 | PIK3CG (0.58) | PIK3CGPIK3CAPIK3CDPIK3CBRAB9A | |
| SCHEMBL470418 | 0.72 | PIK3CG (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBATR | |
| SCHEMBL713914 | 0.70 | PIK3CG (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBRAB9A | |
| SCHEMBL458937 | 0.68 | PIK3CD (0.60) | PIK3CGPIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |
| WO-2010102958-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |