Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.61 |
| ▸ | PDE4A | P27815 | 6/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554332 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL3120368 | 0.89 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL2840403 | 0.87 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL4698717 | 0.87 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL13354257 | 0.85 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL2846822 | 0.82 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL2848106 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL3899046 | 0.81 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE10A | |
| SCHEMBL10721784 | 0.81 | KDM4A (0.60) | PDE4BPDE4APDE4CPDE4DKDM4A | |
| SCHEMBL10645034 | 0.77 | ALDH1A1 (0.56) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| CN-1148189-C | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | ��������ķ������ | 2004-05-05 | — | — | CN | disclosed |
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| CN-1219131-A | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | DARWIN DISCOVERY CO LTD (GB) | 1999-06-09 | — | — | CN | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |