Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 8/20 | 0.43 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705090 | 0.90 | BDKRB1 (0.43) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL14084921 | 0.89 | BDKRB1 (0.47) | BDKRB1RAMP1CALCRLCCNA2CDK2 | |
| SCHEMBL4705761 | 0.89 | BDKRB1 (0.42) | BDKRB1RAMP1CALCRLITGB1ITGA4 | |
| SCHEMBL4705740 | 0.88 | BDKRB1 (0.41) | BDKRB1CALCRLCCNA2CDK2CCNA1 | |
| SCHEMBL4705710 | 0.87 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4702448 | 0.87 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4703537 | 0.85 | BDKRB1 (0.44) | BDKRB1CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL4701074 | 0.84 | KDM2B (0.44) | BDKRB1CCNA2CDK2CCNA1ITGB1 | |
| SCHEMBL4705006 | 0.81 | BDKRB1 (0.65) | BDKRB1CCNA2CDK2CCNA1FPR2 | |
| SCHEMBL4705242 | 0.81 | BDKRB1 (0.65) | BDKRB1CCNA2CDK2CCNA1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |