Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706248 | 0.82 | HRH3 (0.47) | NOTUMGAACHRM2CHRM4CHRM1 | |
| SCHEMBL14202152 | 0.82 | KDM4E (0.55) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL21331595 | 0.81 | CHRM2 (0.62) | NOTUMGAACHRM2CHRM4CHRM1 | |
| SCHEMBL22129196 | 0.77 | HRH3 (0.51) | ALDH1A1HRH3 | |
| SCHEMBL22248030 | 0.76 | NOTUM (0.66) | NOTUMCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5940212 | 0.74 | NOTUM (0.57) | NOTUMGAACHRM2CHRM4CHRM1 | |
| SCHEMBL5940371 | 0.73 | NOTUM (0.56) | NOTUMGAACHRM2CHRM4CHRM1 | |
| SCHEMBL23147045 | 0.73 | ALDH1A1 (0.40) | NOTUMSMN1; SMN2ALDH1A1HRH3MAPT | |
| SCHEMBL10648648 | 0.73 | KMT2A (0.48) | GAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4703874 | 0.72 | NPC1 (0.41) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405848-B1 | TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2008-05-07 | — | — | EP | disclosed |
| US-6924295-B2 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| US-20040171835-A1 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-09-02 | — | — | US | disclosed |
| EP-1405848-A1 | TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171835-A1 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | SREBF1, NR1H2, NR1H3 | NOTUM 944/4885GAA 664/4885SMN1; SMN2 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.